Kuprenil 250mg tbl p/p about the N100

Prescription drug

Manufacturer: Тева
Рецептурный препарат
купренил 250мг тбл п/п об n100
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Brief information

Производитель

Тева

Действующее вещество

Пеницилламин
There are contraindications, specialist advice is required

The appearance of the product may differ from the photos on the site.

General description
Источник:  РЛС

Composition

Film-coated tablets1 table.
active substance: 
penicillamine250 mg
excipients: potato starch-43.75 mg; lactose monohydrate-166.25 mg; povidone-25 mg; talc-10 mg; magnesium stearate-5 mg 
film shell: hypromellose-10.51 mg; macrogol 4000-0.8 mg; titanium dioxide (E171) - 2.51 mg; azorubin dye (E122) - 1.18 mg 

Dosage and administration

Inside, at least 30 minutes before eating, with water, or 2 hours after eating or other drugs.

Wilson-Konovalov Disease

Adults-1.5-2 g/day in fractional doses. After reaching remission of the disease, the dose can be reduced to 0.75 or 1 g/day. In patients with a negative copper balance, the minimum effective dose of penicillamine should be used.

A dose of 2 g / day should be used for no more than 1 year.

Elderly patients — 20 mg/kg/day in fractional doses. The dose should be chosen in such a way as to achieve remission of the disease and keep the negative balance of copper.

Children-usually 20 mg / kg / day in fractional doses.

The minimum dose is 500 mg/day.

Cystinuria

It is best to set the minimum effective dose after quantifying the concentration of amino acids in the urine by chromatographic method.

Dissolution of cystine stones

Adults-1-3 g/day in fractional doses. Keep the concentration of cystine in the urine below 200 mg/l.

Prevention of cystine lithiasis

Adults-0.5-1 g / day until the cystine concentration in the urine is below 300 mg / l.

Elderly patients-prescribe the minimum dose until the cystine concentration in the urine is below 200 mg / l.

Children-assign a minimum dose that allows you to achieve a concentration of cystine in the urine below 200 mg/l.

During treatment, it is recommended to drink a large amount of liquid — at least 3 liters per day. The patient should drink 500 ml of water before going to bed, and then 500 ml at night, when the urine is more concentrated and more acidic than during the day. Usually, the more liquid the patient drinks, the lower their need for penicillamine.

It is also recommended that a diet with a low content of methionine to reduce the synthesis of cystine. Due to the low protein content, this diet is not recommended for children during growth and pregnant women.

Lead poisoning

Adults-1-1. 5 g/day in fractional doses until the release of lead in the urine within 0.5 mg/day.

Elderly patients — 20 mg / kg / day in fractional doses until the release of lead in the urine within 0.5 mg/day.

Children — 20 mg / kg / day.

Rheumatoid arthritis

Adults-250 mg/day for the first month of use. Then the dose is increased every 4-12 weeks by 250 mg until remission of the disease is achieved. After that, apply the minimum effective dose, which allows you to slow down the symptoms of the disease. If the therapeutic effect is not achieved within 6 months of using the drug, treatment should be discontinued.

The maintenance dose is usually 500-750 mg/day. Do not exceed the dose of 1.5 g/day. After reaching remission of the disease, lasting 6 months, the dose of the drug is recommended to gradually reduce by 250 mg every 12 weeks.

Elderly patients-the initial dose should not exceed 250 mg / day during the first month of use of the drug. Then the dose can be increased every 4-12 weeks by 250 mg until remission of the disease is achieved. Do not exceed the dose of 1 g of the drug per day.

Children — 15-20 mg / kg / day. The initial dose is 2.5-5 mg/day, it can be increased gradually every 4 weeks for 3-6 months to the minimum effective dose, but not more than 500 mg.

Systemic scleroderma

250 mg/day for the first month of use. Then the dose is increased every 4-12 weeks by 250 mg to 1 g / day, followed by a decrease to 250-500 mg / day. The effect is estimated after 6-12 months of use of the drug.

Form release

Film-coated tablets, 250 mg.15 table. in a blister made of PVC and aluminum foil; 2 blisters in a cardboard pack. 100 table. in a Bank; 1 Bank in a cardboard pack.

Conditions of supply of pharmacies

By prescription.

Manufacturer

Legal entity in whose name the registration certificate was issued: Teva Pharmaceutical Enterprises Ltd., Israel.

Manufacturer: Teva Operations Poland SP. z OO, Sienkiewicz, 25, 99-300 Kutno, Poland.

Address for receiving claims: Concord Business center, 10 p. 2, Shabolovka str., Moscow, 119049.

Tel. / Fax: (495) 644-22-34/35/36.

The appearance of the product may differ from the photos on the site.

Information about prescription drugs is for professionals only. The information provided should not be used by patients to make an independent decision on the use of the presented drugs and cannot serve as a substitute for a full-time consultation with a doctor.

A description of the active substances of the drug is provided. The scientific information provided is generalized and cannot be used to decide on the possibility of using a specific drug.

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