Viferon 36tys ME / g gel 10ml/12g

Manufacturer: Ферон ООО г.Москва
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Brief information

Производитель

Ферон ООО г.Москва

Действующее вещество

Интерферон альфа-2b

The appearance of the product may differ from the photos on the site.

General description
Источник:  РЛС

Composition

Ointment for external and local use1 g
active substance: 
interferon alpha-2b human recombinant40000 IU
excipients: alpha-tocopherol acetate-0.02 g; anhydrous lanolin-0.34 g; medical vaseline-0.45 g; peach oil-0.12 g; purified water-up to 1 g 
Gel for external and local use1 g
active substance: 
interferon alpha-2b human recombinant36000 IU
excipients: alpha-tocopherol acetate — 0,055 g; methionine — 0,0012 g; benzoic acid — 0,00128 g; citric acid monohydrate — 0.001 g; sodium tetraborate decahydrate — 0,0018 g; sodium chloride 0.004 g; human albumin — 0.002 g; distilled glycerin (glycerol) — 0,02 g; carmellose sodium — 0.02 g; ethanol 95% — 0,055 g; distilled water — up to 1 g 
Suppositories for rectal use1 sup.
active substance: 
interferon alpha-2b human recombinant150000 IU
 500000 IU
 1000000 IU
 3000000 IU
auxiliary substances: ascorbic acid— 0,0054/0,0081/0,0081/0,0081 g; sodium ascorbate— 0,0108/0,0162/0,0162/0,0162 g; alpha-tocopherol acetate— 0,055/0,055/0,055/0,055 g; disodium edetate dihydrate— 0,0001/0,0001/0,0001/0,0001 g; Polysorbate 80 — 0,0001/0,0001/0,0001/0,0001 g; cocoa butter— 0,1958/0,1941/0,1941/0,1941 g; fat pastry or a substitute for cocoa butter, up to 1 g 

Description of the dosage form

Ointment for external and local use

From white-yellow to yellow, with a characteristic smell of lanolin.

Gel for external and local use

An opaque, gel-like mass of white with a grayish tinge of color.

Suppositories for rectal use

Bullet-shaped from white-yellow to yellow. Allowed heterogeneity of color in the form of inclusions or marbling. There is a funnel-shaped recess on the longitudinal section. The diameter of the suppository-no more than 10 mm.

Pharmacodynamics

Interferon alpha-2b human recombinant has antiviral, immunomodulatory, antiproliferative properties, inhibits the replication of RNA and DNA-containing viruses. Immunomodulatory properties of interferon alpha-2b, such as increased phagocytic activity of macrophages, increased specific cytotoxicity of lymphocytes to target cells, cause its mediated antibacterial activity.

In the presence of excipients that are part of the drug (alpha-tocopherol acetate, citric, benzoic, ascorbic acid), increases the specific antiviral activity of human recombinant interferon alpha-2b, increases its immunomodulatory effect (stimulation of the phagocytic function of neutrophils in lesions), which allows to increase the effectiveness of the body's own immune response to pathogenic microorganisms.

In the presence of ascorbic acid and alpha-tocopherol acetate, the specific antiviral activity of interferon alpha-2b increases, its immunomodulatory effect increases, which allows to increase the effectiveness of the body's own immune response to pathogenic microorganisms. When using the drug, the level of secretory IDA increases, the level of IDE is normalized, the endogenous system of interferon alpha-2b is restored. Ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. It was found that when using the drug VIFERON there are no side effects that occur when parenteral administration of interferon alpha-2b drugs, no antibodies are formed that neutralize the antiviral activity of interferon alpha-2b. The use of the drug VIFERON as part of complex therapy can reduce the therapeutic doses of antibacterial and hormonal drugs, as well as reduce the toxic effects of this therapy.

With external and local use, the systemic absorption of interferon is low.

Gel for external and local use

The gel base provides a prolonged effect of the drug.

Suppositories for rectal use

Cocoa butter contains phospholipids, which allow not to use in the production of synthetic toxic emulsifiers, and the presence of polyunsaturated fatty acids facilitates the introduction and dissolution of the drug.

Indications of the drug

Ointment for external and local use

herpetic infections (Herpes simplex types 1 and 2) of the skin and mucous membranes of different localization;

flu and other acute respiratory viral infections in children from 1 year - in complex therapy.

Gel for external and local use

acute respiratory viral infections, including influenza, frequent and long-term acute respiratory viral infections, including complicated bacterial infection - in complex therapy;

prevention of acute respiratory viral infections, including influenza;

recurrent stenosing laryngotracheobronchitis-in complex therapy;

prevention of recurrent stenosing laryngotracheobronchitis;

acute and exacerbation of chronic recurrent herpetic infection of the skin and mucous membranes, including urogenital forms of herpetic infection - in complex therapy;

herpetic cervicitis in complex therapy.

Suppositories for rectal use

acute respiratory viral infections, including influenza, including those complicated by bacterial infection, pneumonia (bacterial, viral, chlamydia) in children and adults - in complex therapy;

infectious and inflammatory diseases of newborns, including premature infants: meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis) - in complex therapy;

chronic viral hepatitis B, C, D in children and adults - in complex therapy, including in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of marked activity, complicated by cirrhosis of the liver;

infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults - in complex therapy;

primary or recurrent herpetic infection of the skin and mucous membranes, localized form, light and moderate course, including urogenital form in adults.

Contraindications

Ointment for external and local use

individual intolerance of the drug components;

children under 1 year of age.

Gel for external and local use and suppositories for rectal use

Hypersensitivity to any of the components of the drug.

Use during pregnancy and lactation

Ointment for external and local use

Since the external and local use of systemic absorption of interferon is low and the drug has an effect only in the lesion, it is possible to use the drug VIFERON during pregnancy and during breastfeeding.

Gel for external and local use

Pregnancy and breastfeeding are not a contraindication for the use of the drug due to the very low absorption of the components. During breastfeeding, do not use in the area of the nipples and areolas.

Suppositories for rectal use

The drug is allowed to be used from 14 weeks of pregnancy. It has no restrictions for use during breastfeeding.

Dosage and administration

Ointment for external and local use

Externally, locally.

With herpetic infection, the ointment is applied in a thin layer to the lesions 3-4 times a day. The duration of treatment is 5-7 days. It is recommended to start treatment immediately when the first signs of lesions of the skin and mucous membranes (itching, burning, redness). In the treatment of recurrent herpes, it is desirable to start treatment in the prodromal period or at the very beginning of the appearance of signs of relapse.

For the treatment of influenza and other SARS, the ointment is applied in a thin layer to the mucous membrane of the nasal passages 3-4 times a day.

Children from 1 year to 2 years-2500 IU (1 pea with a diameter of 0.5 cm) 3 times a day; from 2 to 12 years-2500 IU (1 pea with a diameter of 0.5 cm) 4 times a day; from 12 to 18 years-5000 IU (1 pea with a diameter of 1 cm) 4 times a day. The duration of treatment is 5 days.

The opened aluminum tube is stored in the refrigerator for 1 month.

Gel for external and local use

Externally, locally.

In the complex therapy of SARS, including influenza, long-term and frequent SARS, including complicated by bacterial infection. A strip of gel no longer than 0.5 cm is applied to the pre-dried surface of the nasal mucosa and / or to the surface of the tonsils 3-5 times a day using a spatula or a cotton swab/cotton swab (see note). The course of treatment is 5 days, if necessary, the course can be extended.

Prevention of SARS, including influenza. During the rise of the disease, a strip of gel no longer than 0.5 cm is applied to the pre-dried surface of the nasal mucosa and/or to the surface of the Palatine tonsils 2 times a day for 2-4 weeks.

In the complex therapy of recurrent stenosing laryngotracheobronchitis. A strip of gel no longer than 0.5 cm is applied to the surface of the tonsils with a spatula or cotton swab/cotton swab in the acute period of the disease 5 times a day, for 5-7 days, then 3 times a day for the next 3 weeks.

Prevention of recurrent stenosing laryngotracheobronchitis. A strip of gel no longer than 0.5 cm is applied to the surface of the tonsils with a spatula or cotton swab/cotton swab 2 times a day for 3-4 weeks, the courses are repeated 2 times a year.

In the complex therapy of acute and chronic recurrent herpetic infection (when the first signs of the disease appear or during the period of precursors). A strip of gel no longer than 0.5 cm is applied with a spatula or cotton swab/cotton swab on the pre-dried affected surface 35 times a day for 56 days, if necessary, the duration of the course is increased until the disappearance of clinical manifestations.

In the complex therapy of herpetic cervicitis. 1 ml of the gel is applied with a cotton swab to the pre-cleared mucus surface of the cervix 2 times a day for 7 days, if necessary, the duration of the course can be increased to 14 days.

Note. On the mucous membrane of the nasal cavity, the gel is applied after cleansing the nasal passages, on the surface of the Palatine tonsils-30 minutes after eating. When applying the gel to the Palatine tonsils, do not touch the tonsils with a cotton swab, but only with a gel, the gel at the same time independently flows down the surface of the tonsils. When applying the gel to the cervix, you should first remove the mucus and secretions from the vaults of the vagina and cervix with a cotton or gauze swab.

When applying the gel to the affected areas of the skin and mucous membranes after 30-40 minutes, a thin film is formed, which is again applied to the drug. If desired, the film can be detached or washed off with water before repeated application of the drug.

The opened tube is stored in the refrigerator for no more than 2 months. The drug with a broken integrity of the package and changed color is not suitable for use.

Suppositories for rectal use

Per rectum.

1 sup. contains as an active substance interferon alpha-2b human recombinant in the specified dosages (150000 IU, 500000 IU, 1000000 IU, 3000000 IU).

SARS (including influenza), including complicated bacterial infection, pneumonia (bacterial, viral, chlamydia) in children and adults - in complex therapy. The recommended dose for adults, including pregnant women and children older than 7 years, is the drug VIFERON 500000 IU 1 supp. 2 times a day after 12 hours daily for 5 days. According to clinical indications, therapy can be continued.

Children under 7 years of age, including newborns and premature infants with a gestational age of more than 34 weeks, recommended the use of the drug VIFERON 150000 IU 1 supp. 2 times a day after 12 hours daily for 5 days. According to clinical indications, therapy can be continued. The break between courses is 5 days.

Premature newborns with gestational age less than 34 weeks recommended the use of the drug VIFERON 150,000 IU 1 supp. 3 times a day after 8 hours daily for 5 days. According to clinical indications, therapy can be continued. The break between courses is 5 days.

Infectious and inflammatory diseases of newborns, including premature infants: meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, CMV infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis) - in complex therapy. The recommended dose for newborns, including premature infants with gestational age of more than 34 weeks, is the drug VIFERON 150,000 IU daily for 1 supp. 2 times a day after 12 hours. the Course of treatment-5 days.

Premature newborns with gestational age less than 34 weeks are recommended to use the drug VIFERON 150,000 IU daily for 1 supp. 3 times a day after 8 hours. the Course of treatment-5 days.

The recommended number of courses for various infectious and inflammatory diseases: sepsis-2-3 courses, meningitis-1-2 courses, herpetic infection - 2 courses, enterovirus infection-1-2 courses, CMV infection-2-3 courses, mycoplasmosis, candidiasis, including visceral, - 2-3 courses. The break between courses is 5 days. According to clinical indications, therapy can be continued.

Chronic viral hepatitis B, C, D in children and adults - in complex therapy, including in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of marked activity, complicated by cirrhosis of the liver. The recommended dose for adults-the drug VIFERON 3000000 IU 1 supp. 2 times a day after 12 hours daily for 10 days, then 3 times a week every other day for 6-12 months. The duration of treatment is determined by clinical effectiveness and laboratory indicators.

Children up to 6 months recommended 300000-500000 IU/day; from 6 to 12 months-500000 IU / day.

Children from 1 year to 7 years are recommended 3000000 IU / m2 / day; older than 7 years-5000000 IU /m2 / day.

The drug is used 2 times a day after 12 hours the first 10 days daily, then 3 times a week every other day for 6-12 months. The duration of treatment is determined by clinical effectiveness and laboratory indicators.

The calculation of the daily dose of the drug for each patient is made by multiplying the recommended dose for a given age by the body surface area calculated from the nomogram for calculating the body surface area by height and weight for Garford, Terry and Rourke. The calculation of a single dose is carried out by dividing the calculated daily dose by 2 injections, the resulting value is rounded up to the dosage of the suppository in a larger direction.

In chronic viral hepatitis of marked activity and cirrhosis of the liver before plasmapheresis and / or hemosorption, it is recommended to use the drug VIFERON 150000 IU for children under 7 years of age, and the drug VIFERON 500000 IU for 1 supp. 2 times a day after 12 hours daily for 14 days.

Infectious and inflammatory diseases of the urogenital tract (chlamydia, CMV infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults, including pregnant women — in complex therapy. The recommended dose for adults is the drug VIFERON 500000 IU for 1 supp. 2 times a day after 12 hours daily for 5-10 days. According to clinical indications, therapy can be continued.

Pregnant women from the second trimester of pregnancy (starting from the 14th week of gestation) are recommended to use the drug VIFERON 500000 IU for 1 supp. 2 times a day after 12 hours daily for 10 days, then for 9 days 3 times at intervals of 3 days (on the 4th day) for 1 supp. 2 times a day after 12 h. Then every 4 weeks before delivery-the drug VIFERON 150000 IU 1 supp. 2 times a day after 12 hours daily for 5 days. If necessary, before delivery (from the 38th week of gestation) shows the use of the drug VIFERON 500000 IU 1 supp. 2 times a day after 12 hours daily for 10 days.

Primary or recurrent herpetic infection of the skin and mucous membranes, localized form, light and moderate course, including urogenital form in adults, including pregnant women. The recommended dose for adults is the drug VIFERON 1,000,000 IU of 1 supp. 2 times a day after 12 hours daily for 10 days or more with recurrent infection. According to clinical indications, therapy can be continued. It is recommended to start treatment immediately when the first signs of lesions of the skin and mucous membranes (itching, burning, redness). In the treatment of recurrent herpes, it is desirable to start treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.

Pregnant women from the second trimester of pregnancy (starting from the 14th week of gestation) are recommended to use the drug VIFERON 500000 IU for 1 supp. 2 times a day after 12 hours daily for 10 days, then for 9 days 3 times at intervals of 3 days (on the 4th day) for 1 supp. 2 times a day after 12 h. Then every 4 weeks before delivery-the drug VIFERON 150000 IU 1 supp. 2 times a day after 12 hours daily for 5 days. If necessary, it is indicated before delivery (from the 38th week of gestation) the use of the drug VIFERON 500000 IU for 1 supp. 2 times a day after 12 hours daily for 10 days.

Side effect

Ointment for external and local use

In most cases, the drug VIFERON is well tolerated. When applied to the nasal mucosa, side effects (rhinorrhea, sneezing, burning of the nasal mucosa) are weak and transient and disappear independently after discontinuation of the drug.

Gel for external and local use

In rare cases, you may develop allergic reactions (skin rashes, itching).

Suppositories for rectal use

In rare cases, you may develop allergic reactions (skin rashes, itching). These phenomena are reversible and disappear after 72 hours after discontinuation of the drug.

Interaction

Ointment for external and local use and gel for external and local use

It is not revealed.

Suppositories for rectal use

The drug VIFERON is compatible and well combined with the following drugs-antibiotics, chemotherapy, GCS.

Overdose

Is not installed.

Special instruction

Influence on the ability to drive vehicles and engage in other activities. Is not installed.

Form release

Ointment for external and local use, 40000 IU / g. 12 g in an aluminum tube. 1 tube in a pack of cardboard.

Gel for external and local use, 36000 IU / g. 12 g in an aluminum tube. 1 tube in a pack of cardboard.

Suppositories for rectal use, 150000 IU, 500000 IU, 1000000 IU, 3000000 IU. On 5 or 10 supp. in a contour acheikova packing PVC/PVC. 1 contour cell pack of 10 calipers. or 2 contour cell packages of 5 calipers. in a cardboard box.

Conditions of supply of pharmacies

Without a prescription.

Manufacturer

LLC FERON, Russia. 123098, Moscow, ul. Gamalei, 18.

Tel. / Fax: (499) 193-30-60.

The appearance of the product may differ from the photos on the site.

Information about prescription drugs is for professionals only. The information provided should not be used by patients to make an independent decision on the use of the presented drugs and cannot serve as a substitute for a full-time consultation with a doctor.

A description of the active substances of the drug is provided. The scientific information provided is generalized and cannot be used to decide on the possibility of using a specific drug.

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