Imunofan R-R for I / m and p / C - 1ml amp N5

Prescription drug

Manufacturer: Бионокс НПП ООО
Рецептурный препарат
имунофан р-р для в/м и п/к введ 1мл амп n5
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Brief information

Производитель

Бионокс НПП ООО

Действующее вещество

Аргинил-Альфа-Аспартил-Лизил-Валил-Тирозил-Аргинин

The appearance of the product may differ from the photos on the site.

General description
Источник: РЛС

Composition

Solution for intramuscular and subcutaneous administration 1 ml
Imunofan in cancer 50 mcg
excipients: glycine; sodium chloride; water for injection  

in a contour cell package of 5 or 10 ampoules; in a pack of cardboard 1 or 2 packages.

Suppositories for rectal use 1 sup.
Imunofan in cancer 100 mcg
excipients: purified water; glycine; solid fat; twin 80  

in a contour cell package of 5 or 10 PCs.; in a pack of cardboard 1 or 2 packages.

Nasal spray dosed 1 dose
Imunofan in cancer 50 mcg
excipients: sodium chloride; benzalkonium chloride; glycine; sodium edetate (Trilon B); purified water  

in a plastic bottle with a dosing device of 8.5 ml; in a pack of cardboard 1 bottle.

Description of the dosage form

Solution for injection: colorless transparent liquid.

Suppositories: homogeneous suppositories from white to white with a yellowish tinge of color, torpedo-shaped. A slight specific smell is allowed.

Nasal spray: transparent or slightly opalescent colorless or slightly yellowish liquid. A slight specific smell is allowed.

Pharmacodynamics

The drug has an immunoregulatory, detoxifying, hepatoprotective effect and causes inactivation of free radical and peroxide compounds. Corrects the state of the immune system, restores the balance of redox and anti-oxidative reactions of the body and helps to overcome multiple drug resistance of tumor cells mediated by proteins of the cell's transmembrane transport pump.

The effect of the drug begins to develop within 2-3 hours (fast phase) and lasts up to 4 months (medium and slow phases).

During the rapid phase (duration — up to 2-3 days), the detoxification effect is manifested first of all: the antioxidant protection of the body is enhanced due to stimulation of ceruloplasmin, lactoferrin, and catalase activity; the drug normalizes lipid peroxidation, inhibits the breakdown of cell membrane phospholipids and arachidonic acid synthesis, followed by a decrease in blood cholesterol and the production of inflammatory mediators. In case of toxic and infectious liver damage, the drug prevents cytolysis, reduces the activity of transaminases and the level of bilirubin in the blood serum.

During the middle phase (starts after 2-3 days, duration — up to 7-10 days), phagocytosis reactions and death of intracellular bacteria and viruses increase.

During the slow phase (begins to develop for 7-10 days, duration up to 4 months), the immunoregulatory effect of Imunofan is manifested — the restoration of impaired cellular and humoral immunity. During this period, there is a normalization of the immunoregulatory index, an increase in the production of specific antibodies. The effect of the drug on the production of specific antiviral and antibacterial antibodies is equivalent to the effect of therapeutic vaccines. In contrast to the latter, the drug does not significantly affect the production of IgE class reagin antibodies and does not increase the immediate type of hypersensitivity reaction; Imunofan stimulates the formation of IgA in its congenital insufficiency.

Imunofan effectively suppresses the multi-drug resistance of tumor cells and increases their sensitivity to the action of chemotherapy drugs.

Indications of the drug

Solution for I/m and p / C administration and rectal suppositories

For adults and children over 2 years of age (prevention and treatment):

immunodeficiency and toxic conditions;

chronic inflammatory diseases of various etiologies.

For adults — as an adjuvant for vaccination against bacterial and viral infections.

Metered-dose nasal spray:

For adults and children over 2 years of age (prevention and treatment):

immunodeficiency and toxic conditions;

acute and chronic infectious and inflammatory diseases.

Contraindications

hypersensitivity;

children under 2 years of age.

For the solution for I/m and p/C administration and rectal suppositories (optional) — pregnancy complicated by RH conflict.

Use during pregnancy and lactation

Solution for I / m and p/C administration and rectal suppositories are contraindicated in pregnancy complicated by rhesus conflict.

Due to insufficient knowledge, nasal spray should be used with caution during pregnancy and lactation.

Dosage and administration

P / C or V / m, rectally, intranasally.

Solution for injection: courses, single and daily dose-50 mcg.

Suppositories: single (daily) dose-100 mcg (1 sup.).

Nasal spray: when using the bottle should be held vertically, spray upwards. Remove the protective cap from the sprayer. Before the first application, fill the metering pump by pressing the wide rim of the sprayer 3-4 times. Insert the sprayer into the nasal passage when the head is vertical. Press the sprayer's wide rim all the way down once. One dose of the drug contains 50 mcg of Imunofan. The daily dose should not exceed 200 mcg.

In the treatment of cancer patients in the scheme of radical combined treatment (chemoradiotherapy and surgery):

- 1 time a day, daily, the course of treatment-8-10 injections (8-10 supp. or 1 dose in each nasal passage for 8-10 days) before chemoradiotherapy and surgery, followed by repeated courses throughout the treatment period, with a break of 15-20 days.

In patients with a common tumor process (stage III–IV) of various localization in the form of complex or symptomatic therapy:

- 1 time a day, daily, the course of treatment-8-10 injections (8-10 supp. or 1 dose in each nasal passage for 8-10 days), with a break of 15-20 days and repetition of courses during the entire period of subsequent treatment.

In children with malignant diseases of the hematopoietic and lymphoid systems:

- 1 time a day, daily, the course of treatment-10-20 injections (10-20 supp.). The drug is prescribed during the entire course of chemoradiotherapy and after its completion to prevent the development of toxicosis.

In the complex therapy of acute and chronic infectious and inflammatory diseases accompanied by symptoms of intoxication and immunodeficiency:

- 1 dose (50 mcg) in each nasal passage 2 times a day, daily for 10-15 days.

In the complex therapy of children with laryngeal and oropharyngeal papillomatosis:

- 1 time a day, daily, the course of treatment-10 injections (10 supp.).

For opportunistic infections (CMV and herpetic infection, toxoplasmosis, chlamydia, pneumocystosis, cryptosporidiosis):

- 1 time a day, daily, the course of treatment-15-20 injections (15-20 supp.) or 1 dose in each nasal passage 2 times a day, daily, the course of treatment-10-15 days. If necessary, it is possible to repeat the course in 2-4 weeks.

In the complex therapy of HIV infection:

- 1 time a day, daily, the course of treatment-15-20 injections (15-20 supp. or 1 dose in each nasal passage within 10 to 15 days). If necessary, it is possible to conduct repeated courses in 2-4 weeks.

In chronic viral hepatitis and chronic brucellosis:

- 1 time a day, daily, the course of treatment-15-20 injections (15-20 supp. or 1 dose in each nasal passage for 10-15 days), to prevent relapses, repeat courses should be carried out in 2-3 months (for nasal spray-in 4-6 months).

For diphtheria:

- 1 time a day, daily, the course of treatment-8-10 injections (8-10 supp.). With diphtheria bacteria-1 time after 3 days. The course of treatment is 3-5 injections (3-5 supp.).

In the treatment of burns of the III-IV degree with the phenomena of toxemia, septicotoxemia, in surgical patients with septic endocarditis, long-term non-healing wounds of the extremities, purulent-septic complications:

- 1 time a day, daily, the course of treatment — 7-10 injections (7-10 supp.), if necessary, the course of treatment should be continued up to 20 injections (20 supp.).

For broncho-obstructive syndrome, cholecystopancreatitis, rheumatoid arthritis:

- 1 time after 3 days, the course of treatment-8-10 injections (8-10 supp.), if necessary, the course of treatment should be continued up to 20 injections (20 supp.) according to the same scheme.

In the treatment of psoriasis:

- 1 time a day, daily, the course of treatment-15-20 injections (15-20 supp.).

Vaccination: adults — once per day of vaccination.

Side effect

Individual intolerance is possible.

Interaction

For all dosage forms: possible combination with anti-inflammatory (steroid and non-steroidal) drugs (the effect of Imunofan does not depend on the production of PGE 2 ).

Injection solution: no cases of interaction of Imunofan with other drugs have been reported.

Nasal spray: increases the effectiveness of other types of drug therapy; the use of Imunofan helps to overcome resistance to GCS therapy.

Special instruction

As a result of phagocytosis activation, short-term exacerbation of chronic inflammation foci supported by the persistence of viral or bacterial antigens is possible.

Manufacturer

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The appearance of the product may differ from the photos on the site.

Information about prescription drugs is for professionals only. The information provided should not be used by patients to make an independent decision on the use of the presented drugs and cannot serve as a substitute for a full-time consultation with a doctor.

A description of the active substances of the drug is provided. The scientific information provided is generalized and cannot be used to decide on the possibility of using a specific drug.

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